XLS Medical Appetite Reducer - Appetite Suppressant and Hunger Control for a more Efficient Weight Loss - 60 Capsules, 10 Days Treatment

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InQpharm NA, the company that brought plant-based, weight-loss system bmiSMART to the US, has announced the publication of a double-blind, placebo-controlled 14-week study in Advancement in Medicinal Plant Research, revealing significant benefits of appetite reduction on weight loss. Hunger Buddy must be taken as a whole capsule with a full glass of water (approximately 250ml). Do not open the capsule and avoid taking it in powder form to avoid choking. Stool frequency was assessed based on bowel movements recorded in the subject diaries 3 days a week. Physical activity was recorded using validated International Physical Activity Questionnaire, Short Form (IPAQ-SF) [ 36] during all study visits from visit 2 to visit 6.

For beneficial action of fibres on gastrointestinal transit, it is recommended to drink at least 2L of water a day. Slight constipation could occur in case of limited liquid intake. If constipation persists despite adequate fluid intake, please consult your healthcare professional. Dietetic and pharmaceutical preparations for the treatment of metabolic syndrome and related diseases namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia and obesity, general weight management, treatment of obesity and prevention of obesity; chemical preparations for medical and pharmaceutical purposes for the treatment of metabolic syndrome and related diseases for the treatment of metabolic syndrome and related diseases namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia and obesity, general weight management, treatment of obesity and prevention of obesity; dietary supplement for humans for general health and wellbeing; pharmaceutical and nutraceutical preparations primarily of plant extracts adapted for dietetic use for the treatment and prevention of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity; pharmaceutical and nutraceutical preparations primarily of plant extracts adapted for medical use for the treatment and prevention of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity; pharmaceutical and nutraceutical preparations primarily of plant extracts adapted for nutritional use for the treatment and prevention of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity; pharmaceutical and nutraceutical preparations primarily of plant extracts adapted for pharmaceutical use for the treatment and prevention of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity; plant extracts adapted for the treatment of metabolic syndrome and related diseases for the treatment and prevention of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity, general weight management, treatment of obesity, prevention of obesity and blood glucose management; medicated food supplements for the treatment of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity, general weight management, treatment of obesity and prevention of obesity; weight management supplements; nutritional food additives for medical purposes in the nature of food extracts derived from plant extracts, for the treatment of metabolic syndrome and related diseases, namely, diabetes, hypoglycaemia, hypertension, heart diseases, cardiovascular diseases, hyperlipidaemia, hypercholesterolemia, anemia, bulimia nervosa, anorexia and obesity, general weight management, treatment of obesity and prevention of obesity; plant extracts for medical use namely extract of Amorphophallus konjac; nutritional supplements to reduce, control appetite; nutritional sup Unfortunately, although obesity stems from consuming more calories than the body burns, more than 80% of overweight and obese individuals have trouble losing and maintaining weight loss through diet and exercise alone. These individuals recognise the serious health consequences of being overweight and often undertake drastic measures, including drug therapies and invasive surgeries, to achieve a healthier weight. Non-invasive weight management solutions As demonstrated by Zaluvida Group’s research and evidenced in InQpharm’s three bmiSMART products, efficacious, safe and easy to apply approaches to weight management do exist. They also allow adaption to individual dietary habits (such as preference for fatty foods or carbohydrate-rich diets) and can help to overcome initial hunger sensations while individuals are transitioning to a healthier diet. The mean reduction in waist circumference was more pronounced in both IQP-AE-103 groups, compared with that in the placebo group at the end of the study. Subjects in the high-dose IQP-AE-103 arm had a mean reduction in waist circumference of 4.1 ± 3.3 cm, whereas the mean reduction in the low-dose IQP-AE-103 arm was 2.5 ± 2.4 cm, in contrast to only 0.9 ± 1.6 cm reported in the placebo group ( and versus placebo, respectively). Also, there were statistically significant differences in the percentage of subjects with reduction in hip circumference between the study groups at week 12, between high-dose IQP-AE-103 and the placebo group (91.4% vs. 54.8%; ), as well as between low-dose IQP-AE-103 and placebo groups (80% vs. 54.8%; ), however, not between low- and high-dose IQP-AE-103 groups ( ). No statistically significant differences in waist-to-hip ratio between the study groups were reported at week 12.

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At the end of the study, 97.1% of the subjects in the high-dose IQP-AE-103 group and 85.3% in the low-dose group rated the benefits of the treatment as “good” or “very good” compared with 10% in the placebo group. However, investigator rated the benefit as “good” or “very good” for 94.1% and 85.3% of the subjects in high- and low-dose IQP-AE-103 groups, respectively, compared with 6.7% for placebo subjects. Based on the physicochemical properties of okra pods and inulin, and the fat binding capacity shown in vitro, it was hypothesized that a product containing powdered okra pods and inulin could potentially contribute to weight loss. Hence, the primary objective of this randomised, double-blind, placebo-controlled clinical study was to evaluate the weight loss potential of IQP-AE-103 over the period of 12 weeks in overweight and moderately obese subjects. In this study, it was demonstrated that in conjunction with a hypocaloric diet, IQP-AE-103 at both low dose (990 mg okra and 255 mg inulin/day) and high dose (1980 mg okra and 510 mg inulin/day) causes significant weight loss and that the effects are greater than those in the placebo. Baseline body weight was reduced by 5.03 ± 2.50 kg in the high-dose group and by 3.01 ± 2.19 kg in the low-dose group, compared with 0.98 ± 2.06 kg in the placebo group. Also, for the high-dose group, weight loss effect due to IQP-AE-103 consumption was observed as early as at 2 weeks of treatment and was sustained over the course of the 12-week intake period. More importantly, the proportion of subjects who lost at least 5% of baseline body weight was 60.0% in the high-dose IQP-AE-103 group, a proportion that is significantly higher than that in the low-dose and the placebo groups. Such weight loss due to the intake of IQP-AE-103 is considered to be of clinical relevance as European Medicines Agency associates a weight loss of 5% or more with a decrease of disease risk factors associated with overweight and obesity [ 38]. Subgroup analysis showed that although both IQP-AE-103 high- and low-dose consumptions led to significant weight loss in overweight subjects, for moderately obese subjects, only high dose caused a significant body weight reduction. Subgroup analysis also showed a statistically significant weight loss in both high- and low-dose IQP-AE-103 groups in subjects aged 41–65 years when compared with placebo group, whereas only the high-dose group showed a significant weight loss versus placebo in subjects aged 18–40 years. During the intervention period, no significant changes in fasting blood glucose and HbA1c levels were observed between the study groups. 67% of subjects in the IQP-AE-103 high-dose group had a reduction in triglyceride levels compared with 37% in the placebo group ( ). Changes in total/low-density lipoprotein (LDL)/high-density lipoprotein (HDL) cholesterol were not significant at the end of the study, but a post hoc subgroup analysis performed with subjects with baseline total cholesterol level above 6.2 mmol/L revealed pre-post reductions in total cholesterol of 1.22 ± 1.10 mmol/L ( ), 0.58 ± 0.90 mmol/L ( ), 0.13 ± 0.31 mmol/L ( ), and reductions in LDL cholesterol of 1.18 ± 1.06 mmol/L ( ), 0.49 ± 0.74 mmol/L ( ), and 0.23 ± 0.29 mmol/L ( ), in high-dose, low-dose IQP-AE-103, and placebo groups, respectively.

The primary endpoint of this study was the comparison of the mean body weight (kg) change between IQP-AE-103 high dose and placebo after 12 weeks of intervention from baseline, in overweight and moderately obese subjects. The evaluation of the efficacy of IQP-AE-103 was based on the null hypothesis that there are no statistical differences between IQP-AE-103 and placebo in mean reduction of body weight after 12 weeks of treatment. The nonparametric Mann–Whitney U test for independent samples was applied. The testing was carried out by the determination of the rank sum of individual body weight changes. Obesity is the fastest growing chronic disease — one that affects people of all ages. Its concomitant health risks are well documented, as is its role in the progression of other diseases, including cardiovascular disease, type 2 diabetes, respiratory problems and osteoarthritis. 1 Objective. This study was performed to determine the efficacy and tolerability/safety of IQP-AE-103 on body weight reduction in overweight to moderately obese adults. Methods. A double-blind, randomized, placebo-controlled trial involved one hundred and eight subjects (BMI between 25 and 35 kg/m 2) that were randomly assigned to either the low-dose or the high-dose IQP-AE-103 group, or the placebo group. Following a 2-week run-in period, subjects received two capsules of investigational product after three daily main meals for 12 weeks. Subjects were instructed to maintain a nutritionally balanced hypocaloric diet according to the individual’s energy requirement. Body weight, body fat, and waist and hip circumference were measured at baseline, and after 2, 4, 8, and 12 weeks. Subjects also rated their feelings of hunger and fullness using visual analogue scales, and food craving on a 5-point scale at the same time intervals. Blood samplings for safety laboratory parameters were taken before and at the end of the study. Results. After 12 weeks of intake, the high-dose IQP-AE-103 group had a significantly greater weight loss compared with the placebo (5.03 ± 2.50 kg vs. 0.98 ± 2.06 kg, respectively; ) and the low-dose group (3.01 ± 2.19 kg; ). The high-dose group experienced a decrease in body fat of 3.15 ± 2.41 kg compared with a decrease of 0.23 ± 2.74 kg for the placebo group ( ). High-dose IQP-AE-103 also decreased the feeling of hunger in 66% subjects. A beneficial effect of IQP-AE-103 on the lipid metabolism was also demonstrated in the subgroup of subjects with baseline total cholesterol levels above 6.2 mmol/L. No side effects related to the intake of IQP-AE-103 were reported. Conclusions. These findings indicate that IQP-AE-103 could be an effective and safe weight loss intervention. This trial is registered with NCT03058367. 1. Introduction Don't take this product if you are allergic to sulphur-containing products (such as sulfites) or any of the ingredients listed. If you experience any allergic symptoms, such as skin rashes or difficulty in breathing or any other side effects, please consult your doctor immediately.Our study has several limitations. One limitation is that it was performed over a short period of only 12 weeks, with no follow-up conducted after the study was finished and no weight maintenance phase after the initial weight loss. As such, the study provides no information about the effects of IQP-AE-103 on long-term weight maintenance and on other obesity-related conditions such as diabetes or cardiovascular disease. In addition, the study included subjects of a wide age range. Although the distribution of different age groups was not substantially different between groups in the current study, it may be helpful to include age as a stratification factor in future study. Changes in gut microbiota composition occur with age [ 52], and it has been shown that altered gut microbiota may be associated with obesity [ 53], since IQP-AE-103 contains fibres and polysaccharides from okra pod and inulin, it is likely that the composition of the intestinal gut microbiota may be positively influenced by the consumption of IQP-AE-103. Hence, analysis of gut microbiota changes in overweight and obese subjects of different age groups may provide additional knowledge regarding the effect of IQP-AE-103. Moreover, appetite sensations in the study were assessed using VAS and rating scales, which were not validated for the specific use to measure changes in a similar study design. Last but not least, self-reporting of dietary intake by study subjects, applied for reasons of practicality, may be a limitation. It is known that factors such as gender and weight status affect subjects’ behavior in reporting energy intake; for example, females tended to underreport compared with males, and increasing weight status was associated with an increase in underreporting of energy intake [ 54]. As such, results obtained in the current study, primarily evaluating weight loss, on IQP-AE-103’s effect on appetite sensations remain exploratory. To evaluate a potential effect of IQP-AE-103 on food/energy intake, quantification of actual calorie intake by recording food consumption at an “ad libitum” lunch may be considered in future studies. The animal and in vitro data used to support the findings of this study are currently under embargo, whereas the research findings are commercialized. Data requests will be considered by the corresponding author 12 months after publication of this article. Conflicts of Interest Our findings stand in line with results obtained by Wang et al., who demonstrated that okra intake decreased serum and hepatic total cholesterol and triglyceride levels, and enhanced fecal excretion of bile acids in mice [ 46]. In other study, Kahlon et al. showed that okra polysaccharides have strong bile acid binding properties [ 47]. Furthermore, Chen et al. reported that okra powder showed oil-binding capacities and cholesterol adsorption properties [ 48]. Additionally, results from animal study by Han et al. imply that inulin may also possess a fat-binding property besides its known beneficial effect as prebiotic, which contributed to a lower triglyceride and cholesterol levels in rats fed with high fat diet in the experiments [ 49]. Thus, the cholesterol-lowering effect of IQP-AE-103 could possibly be related to the physicochemical properties of both okra and inulin.